New exogenus factors of musculoskeletal health and diseases

Dr. Urs Müller, Institute of Evaluative Research in Orthopedic Surgery, University of Bern
Low back pain in the Swiss popualtion
Low back pain is very common in Switzerland as elsewhere in Europe. Low back pain is expensive for our health care system and for the working sphere. If we want to assess the success of a treatment for low back pain, we have to know its natural history. Today this knowledge is insufficient for a modern evaluation. In times of increasing cost pressure we should also define the financial impact of the natural history of low back pain. The cost analysis will make possible a sound evaluation about the effectiveness of therapeutic measures. References about the natural history of low back pain in relation to its costs were not found. Based on a nationwide crossectional study we could define the number of low back pain patients in Switzerland. The longitudinal follow-up of these individuals will deliver the needed norm values.
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Prof. Reto Krapf, University Hospital Bruderholz
Neutralization of diet-induced acid and bone and muscle
Ingestion of diets high in animal protein and wheat flour induces a chronic acid load. There is evidence that high acid loads leads to calcium loss from bone, stimulate bone resorption, inhibit bone formation and result in loss of skelettal muscle mass. Furthermore, high acid loads result in many endocrine and metabolic alterations with potentially detrimental effects on bone and muscle.
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Prof. Dr. Theo Wallimann, Institut für Zellbiologie, ETH Zürich
Bioenergetics of human osteoblast-like cells in vitro
Creatine supplementation, first employed by athletes to enhance muscle mass, power and performance, is increasingly recognized as a potentially important adjuvant therapeutic agent for patients with different muscle diseases as well as other neuromuscular and neuro-degenerative diseases. Supplementation with this inexpensive natural body substance is envisaged to have a great socio-economic impact on musculo-skeletal health for the general public, as well as for a large number of different patients, e.g. for muscle maintenance and rehabilitation. Recently, we could show that creatine has a favorable effect on isolated bone forming cell by stimulating cell growth and calcification in cell culture. This could indicate that this intervention, thought as a safe and economical adjuvant treatment method, might also represent a potentially valid strategy for the prevention and treatment of osteoporosis.
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